Diabetes Mellitus has become a worldwide epidemic, affecting 400 million people. Effective and efficient monitoring of diabetic control and diagnosis requires a good marker for estimation of the average blood glucose over a longer period. HbA1c meets this requirement for such a reliable compass to guide therapy.
For optimal clinical use (e.g. uniform clinical guidelines, uniform reference values, comparison of scientific studies) equivalence of results is desirable: results of any laboratory anywhere in the world and irrespective the routine method used, should be the same. This requires standardization. The IFCC Reference Measurement Procedure for HbA1c is the analytical anchor for the worldwide standardization of all routine HbA1c assays.